We specialize in RNA Nanoparticle Design and Production


About US Our Start

ExonanoRNA LLC was established in 2017 in Columbus, Ohio to fill the need for commercial supply of high-quality RNA nanoparticles for research and pre-clinical studies. We have assembled a team of experienced scientists to efficiently coordinate a multidisciplinary effort in transitioning bio-nanotechnology, and especially RNA nanotechnology, from the bench to the clinic. We develop a broad range of innovative products in the primary area of RNA nanotechnology-based platforms for next generation targeted drug delivery and disease diagnosis.

RNA Nanotechnology has great promise to facilitate next generation pharmaceutical research and drug development. Based on the pioneering work of Dr. Peixuan Guo’s research on RNA nanotechnology for more than 20 years (https://rnanano.osu.edu/Guo/peixuanguo.html ), RNA nanotechnology has shown to overcome limitations of conventional cancer therapeutics and to provide specific delivery of drugs (siRNA, miRNA and chemicals) at significantly enhanced therapeutic efficacy and reduced toxicity and side effects.

  • 1. Pi F, …Guo P. Nature Nanotechnology. 2018; 13(1):82-89.
  • 2. Shu D, … Guo P. Nature Nanotechnology 2011; 6(10):658-67.
  • 3. Guo P. Nature Nanotechnology. 2010;5:833.


Product and Services

ExonanoRNA is pleased to offer the best customized RNA nanoparticles with large scale and high purity. The RNA nanoparticles can be designed with desired modifications on backbones or bases (e.g. 2’O-Methyl, 2′-Fluoro, thioates, etc.), or with modifications (biotin, streptavidin, fluorophores, etc.).
Fluorescent labeled RNA nanoparticles can be used for in vitro and in vivo caner targeting study; RNA nanoparticles harboring functional therapeutics (siRNA, miRNA, chemical drug) can be used for in vitro and in vivo cancer inhibition study; customized RNA nanoparticles with difference modifications can be used for your specific needs of projects; customized siRNA Delivery via Exosomes can be a platform for the in vivo study of siRNA under your research.

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Advantages of RNA Nanoparticles for Therapy